22 lb unstuffed turkey. What is the oven temperature and time to roast? Thank you.

Unstuffed it should take between 4 to 5 hours at 325° F. Stuffed will take longer and brined will take less time though!

There are other options though like using a high temperature to crisp up the skin (this recipe calls for a 15 pound turkey, but should be adjustable to 22!): https://food52.com/recipes/38997-barbara-kafka-s-simple-roast-turkey

Just make sure that a meat thermometer reads the internal temperature at 165° F.

That's a big bird!! This article should help you out while I do the math on it! https://food52.com/blog/11646-the-essential-numbers-a-guide-to-times-and-temps-for-cooking-your-bird