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Internal temperature would be the best way to tell when your pork is done. Between 145 and 160 degrees is considered safely cooked for pork (and remember that it will continue cooking for a while after the meat is removed from the oven). You should insert your thermometer at the thickest portion of the meat to gauge its temperature.
As far as cooking times, I would start testing early! Bone-in meat takes much longer to cook than boneless meat because it provides a buffer to the heat.