Peel core and chop the apples and the pears. Heat a skillet over medium high heat (not non-stick!!!!) Add the butter and let it melt and sizzle.
Add the apples and pear pieces. Saute 1 minute. Add the lemon juice and zest. Add the sugar and let it bubble and reduce a little. Add the cinammon, salt and pepper, vanilla and the whiskey. Saute another minute. Make a slurry out of the water and flour. Add to pan and stir in.
Add contents of the pan to prepared pie crust. Top with the frozen berries, arranging evenly over the top. Top with crumble topping. Bake at 375 in a preheated oven until crumble top is brown and pie is fragrant (about 20-30 minutes depending on your oven.)