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I would -- consider that buttermilk is probably 1 - 2% fat, so check the kefir's fat content. You might want to dilute it a but if the fat content is higher. Also, if it's considerably thicker, also consider dilution. But as I understand the chemistry, it's going to provide an acid form of milk, and it should be delicious. Recently I made a favorite cornbread that uses yogurt with buttermilk instead, and it was wonderful.
Never tried it, but with same amt of fat, protein, and calories, I would think it would work just fine.