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Not much actually, in fact I believe some folks use the name and cheeses interchangeably - they are both soft white fresh cheeses with a nice mild flavor, and neither is particularly "melty" - if you want a melting cheese rather than a crumbling one you might think of Oaxacan instead
aargersi is right, there is virtually no difference between the two. Traditionally, queso blanco is made from cow's milk, whereas fresco may be made from a mixture of cow's milk and goat's milk.