Can you substitute plain 2% milk for buttermilk in a buttermilk pie?

Buttermilk has a wonderful tang, which is what makes it so good in a pie. Milk that hasn't been cultured just won't have the flavor. It will be a custard pie, not a buttermilk pie! It will be good, just not the same.

It worked ok! A little different flavor, but the texture was fine. I added cinnamon for a fall flair, and it was a hit!

May I respectfully suggest you bake a different pie this time? But do try a buttermilk pie when you can. They are delicious.

To get a flavor closer to buttermilk, you can squeeze a lemon into the plain milk. Not exact but closer!

It will not have anything like the flavor.

It will not have anything like the flavor.