Yes! Though different, it will be very good. Be sure to add 1/2 teaspoon of baking soda for every 8 ounces of buttermilk to neutralize the acid, or your rise will be a bit anemic.
It works for me. In the recipe I created, I substitute most anything (buttermilk, yogurt, sour cream, heavy cream, etc) for the dairy component. Flavor will vary a bit with each.
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