I've never tried this, but here's a pumpkin pie recipe from teh Splenda website:
http://recipes.splenda.com/recipes/1397029-The-Great-Pumpkin-Pumpkin-Pie
I don't see why not. Pumpkin pie is essentially a custard. The eggs and the pumpkin provide most of the texture. The sugar serves mostly as a sweetener. As far as storage is concerned, i think it might dry out a little more easily becuase sugar holds on to moisture and it may not brown as well on the top because there will be no carmelization
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http://recipes.splenda.com/recipes/1397029-The-Great-Pumpkin-Pumpkin-Pie