Why are you avoiding it? If it is to stay away from fish, soy and a little bloop of ketchup might give a similar tangy-salty profile without having to go out and source tamarind. If you don't mind fish, A-1 is a good choice.
I was thinking along the same lines as pierino and Sam1148--I'd use fish sauce plus some tamarind. Then I started thinking, that mamilli08 might not be in a group of people who have fish sauce and tamarind but not Worcestershire. And I decided that it depends on the recipe and what's in the cupboard. Leaving it out without substitute could even be an option.
I'd go for soy sauce. A bit of red pepper and vinegar, warm that up in a microwave. Anchovies would be next elements--but if you don't have W sauce you probably don't have anchovey--or your asking because of allergery.
The next elements are sweet...a bit a sugar, a bit tamaraid..So add a tsp of steak sauce like A1. Then a bit of onion and garlic.
I'd agree fish sauce for most things, even though Worcestershire also has fruit in it unlike fish sauce. For a burger, though, I'd say sub with some kind of dry spice blend.
I have used soy when I'm out. It's not the same and you don't want to use much. In a burger, you could also just leave it out since there isn't really a substitute.
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The next elements are sweet...a bit a sugar, a bit tamaraid..So add a tsp of steak sauce like A1. Then a bit of onion and garlic.