Could this be done in a slow cooker?

Certainly it can be done in a slow cooker. Doing a brisket in the crockpot is my go to way to produce a nice tender, flavorful brisket. It will take about 8-10 hours on low, and don't be tempted to hit "hi" and go shorter time either. Have a look at the recipe here, https://toriavey.com/savory-slow-cooker-brisket/
for a basic recipe, and links to other similar ones. You probably won't want or need all that broth and wine, because you don't have to worry about evaporation in a slow cooker. I generally have found I only need about half of what is called for in a traditional recipe braising on the stove or in the oven. You can always add more during cooking if you think you need it, but I never have. I also like to do the cooking overnight, so I can chill the meat a few hours before reheating, slicing and serving. It slices easier that way, and you can degrease the sauce easier too.