I think if you want to forgo the traditional bechamel, it should work. But for me, the acidic (tomatoes) and meaty texture of the bolognese, alongside the rich, smooth bechamel, creates a nice contrast within the lasagna's layers that might be more interesting.
I don't think it would be a bad choice at all. It sort of combines the bechamel and bolognese in this recipe into one: http://food52.com/recipes/20687-birthday-lasagna
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